› 1cp8

Solution NMR

NMR STRUCTURE OF DNA (5'-D(TTGGCCAA)2-3') COMPLEXED WITH NOVEL ANTITUMOR DRUG UCH9

Released:
DOI: 10.2210/pdb1cp8/pdb
PDB entry 1cp8 coloured by chain, front view.
PDB entry 1cp8 coloured by chain, side view.
PDB entry 1cp8 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Solution structure of the novel antitumor drug UCH9 complexed with d(TTGGCCAA)2 as determined by NMR.
Katahira R, Katahira M, Yamashita Y, Ogawa H, Kyogoku Y, Yoshida M
Nucleic Acids Res 26 744-55 (1998)
PMID: 9443966

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113552 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecules (2 distinct):
DNA (5'-D(P*TP*TP*GP*GP*CP*CP*AP*A)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 8 nucleotides
Theoretical weight: 2.43 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

Carbohydrate polymer : NEW Components: DDA, DDL, DRI
Carbohydrate polymer
3 bound ligands:
Ligand DDA 2 x DDA
Ligand DXA 2 x DXA
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

2 review citations

The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives.
Lombó et al. (2006)
1 more

8 mentions without citation

A large-scale association study for nanoparticle C60 uncovers mechanisms of nanotoxicity disrupting the native conformations of DNA/RNA.
Xu et al. (2012)
7 more