› 1cu4

X-ray diffraction
2.9Å resolution

CRYSTAL STRUCTURE OF THE ANTI-PRION FAB 3F4 IN COMPLEX WITH ITS PEPTIDE EPITOPE

Released:
DOI: 10.2210/pdb1cu4/pdb
PDB entry 1cu4 coloured by chain, front view.
PDB entry 1cu4 coloured by chain, side view.
PDB entry 1cu4 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Antibody binding defines a structure for an epitope that participates in the PrPC-->PrPSc conformational change.
Kanyo ZF, Pan KM, Williamson RA, Burton DR, Prusiner SB, Fletterick RJ, Cohen FE
J Mol Biol 293 855-63 (1999)
PMID: 10543972

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-211555 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
FAB LIGHT CHAIN Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.08 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
FAB HEAVY CHAIN Chain: H
Molecule details ›
Chain: H
Length: 217 amino acids
Theoretical weight: 23.34 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
RECOGNITION PEPTIDE Chain: P
Molecule details ›
Chain: P
Length: 10 amino acids
Theoretical weight: 1.13 KDa

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 39.47Å b: 77.35Å c: 134.07Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.159 0.159 0.268

Quick links

Citations

5 review citations

Probing the origins, diagnosis and treatment of amyloid diseases using antibodies.
Dumoulin et al. (2004)
4 more

7 mentions without citation

Neutralizing ebolavirus: structural insights into the envelope glycoprotein and antibodies targeted against it.
Lee et al. (2009)
6 more