› 1cx4

X-ray diffraction
2.45Å resolution

CRYSTAL STRUCTURE OF A DELETION MUTANT OF THE TYPE II BETA REGULATORY SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE

Released:
DOI: 10.2210/pdb1cx4/pdb
PDB entry 1cx4 coloured by chain, front view.
PDB entry 1cx4 coloured by chain, side view.
PDB entry 1cx4 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase: crystal structure of the type II beta regulatory subunit.
Diller TC, Xuong NH, Taylor SS
Structure 9 73-82 (2001)
PMID: 11342137

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146155 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
cAMP-dependent protein kinase type II-beta regulatory subunit Chain: A
Molecule details ›
Chain: A
Length: 305 amino acids
Theoretical weight: 34.16 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P12369 (Residues: 112-416; Coverage: 73%)
Gene name: Prkar2b
Sequence domains: Cyclic nucleotide-binding domain
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand CMP 2 x CMP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P61
Unit cell:
a: 161.62Å b: 161.62Å c: 39.66Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.176 0.176 0.198
Expression system: Escherichia coli

Quick links

Citations

18 review citations

A historical overview of protein kinases and their targeted small molecule inhibitors.
Roskoski R. (2015)
17 more

26 mentions without citation

Therapeutic strategies for anchored kinases and phosphatases: exploiting short linear motifs and intrinsic disorder.
Nygren et al. (2015)
25 more