› 1d0d

X-ray diffraction
1.62Å resolution

CRYSTAL STRUCTURE OF TICK ANTICOAGULANT PROTEIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR

Released:
DOI: 10.2210/pdb1d0d/pdb
PDB entry 1d0d coloured by chain, front view.
PDB entry 1d0d coloured by chain, side view.
PDB entry 1d0d coloured by chain, top view.
Source organisms:
Primary publication:
Structure of tick anticoagulant peptide at 1.6 A resolution complexed with bovine pancreatic trypsin inhibitor.
St Charles R, Padmanabhan K, Arni RV, Padmanabhan KP, Tulinsky A
Protein Sci 9 265-72 (2000)
PMID: 10716178

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133754 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tick anticoagulant peptide Chain: A
Molecule details ›
Chain: A
Length: 60 amino acids
Theoretical weight: 6.99 KDa
Source organism: Ornithodoros moubata
UniProt:
  • Canonical: P17726 (Residues: 1-60; Coverage: 100%)
Structure domains: Pancreatic trypsin inhibitor Kunitz domain
Pancreatic trypsin inhibitor Chain: B
Molecule details ›
Chain: B
Length: 58 amino acids
Theoretical weight: 6.53 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00974 (Residues: 36-93; Coverage: 73%)
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P41
Unit cell:
a: 46.87Å b: 46.87Å c: 50.35Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.189 0.211

Quick links

Citations

3 review citations

Evolutionary families of peptidase inhibitors.
Rawlings et al. (2004)
2 more

3 mentions without citation

Are ticks venomous animals?
Cabezas-Cruz et al. (2014)
2 more