› 1d10

X-ray diffraction
1.5Å resolution

STRUCTURAL COMPARISON OF ANTICANCER DRUG-DNA COMPLEXES. ADRIAMYCIN AND DAUNOMYCIN

Released:
DOI: 10.2210/pdb1d10/pdb
PDB entry 1d10 coloured by chain, front view.
PDB entry 1d10 coloured by chain, side view.
PDB entry 1d10 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Structural comparison of anticancer drug-DNA complexes: adriamycin and daunomycin.
Frederick CA, Williams LD, Ughetto G, van der Marel GA, van Boom JH, Rich A, Wang AH
Biochemistry 29 2538-49 (1990)
PMID: 2334681

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113570 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*AP*TP*CP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand DM1 1 x DM1
Ligand SPM 1 x SPM
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P41212
Unit cell:
a: 28.11Å b: 28.11Å c: 53.08Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 not available not available
Expression system: Not provided

Quick links

Citations

32 review citations

Thermodynamics of drug-DNA interactions.
Haq I. (2002)
31 more

18 mentions without citation

Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.
Sheng et al. (2013)
17 more