› 1d1j

X-ray diffraction
2.2Å resolution

CRYSTAL STRUCTURE OF HUMAN PROFILIN II

Released:
DOI: 10.2210/pdb1d1j/pdb
PDB entry 1d1j coloured by chain, front view.
PDB entry 1d1j coloured by chain, side view.
PDB entry 1d1j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray structure determination of human profilin II: A comparative structural analysis of human profilins.
Nodelman IM, Bowman GD, Lindberg U, Schutt CE
J Mol Biol 294 1271-85 (1999)
PMID: 10600384

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152792 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Profilin-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 139 amino acids
Theoretical weight: 14.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35080 (Residues: 2-138; Coverage: 98%)
Gene name: PFN2
Sequence domains: Profilin
Structure domains: Dynein light chain 2a, cytoplasmic

Ligands and Environments

3 bound ligands:
Ligand SO4 4 x SO4
Ligand PG6 1 x PG6
Ligand PG5 1 x PG5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: P21
Unit cell:
a: 71.14Å b: 44.8Å c: 89.6Å
α: 90° β: 98.59° γ: 90°
R-values:
R R work R free
0.22 0.216 0.268
Expression system: Escherichia coli

Quick links

Citations

6 review citations

The role of profilin complexes in cell motility and other cellular processes.
Witke W. (2004)
5 more

8 mentions without citation

Structure and functions of profilins.
Krishnan et al. (2009)
7 more