› 1d24

X-ray diffraction
1.9Å resolution

CRYSTAL AND MOLECULAR STRUCTURE OF A DNA DUPLEX CONTAINING THE CARCINOGENIC LESION O6-METHYLGUANINE

Released:
DOI: 10.2210/pdb1d24/pdb
PDB entry 1d24 coloured by chain, front view.
PDB entry 1d24 coloured by chain, side view.
PDB entry 1d24 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Crystal and molecular structure of a DNA duplex containing the carcinogenic lesion O6-methylguanine.
Ginell SL, Kuzmich S, Jones RA, Berman HM
Biochemistry 29 10461-5 (1990)
PMID: 2271657

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113585 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*CP*(6OG)P*CP*G)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 6 nucleotides
Theoretical weight: 1.82 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand 6OG 2 x 6OG

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 17.85Å b: 30.87Å c: 43.98Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 not available not available
Expression system: Not provided

Quick links

Citations

2 review citations

Crystal structures of nucleic acids and their drug complexes.
Neidle et al. (1998)
1 more

1 mention without citation

Transcription elongation past O6-methylguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase.
Dimitri et al. (2008)