› 1d2q

X-ray diffraction
2.8Å resolution

CRYSTAL STRUCTURE OF HUMAN TRAIL

Released:
DOI: 10.2210/pdb1d2q/pdb
PDB entry 1d2q coloured by chain, front view.
PDB entry 1d2q coloured by chain, side view.
PDB entry 1d2q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity.
Cha SS, Kim MS, Choi YH, Sung BJ, Shin NK, Shin HC, Sung YC, Oh BH
Immunity 11 253-61 (1999)
PMID: 10485660

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo trimer
Assembly name:
PDBe Complex ID:
PDB-CPX-156231 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor ligand superfamily member 10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 168 amino acids
Theoretical weight: 19.52 KDa
Source organism: Homo sapiens
Expression system: Bacteria
UniProt:
  • Canonical: P50591 (Residues: 114-281; Coverage: 60%)
Gene names: APO2L, TNFSF10, TRAIL
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MACSCIENCE
Spacegroup: P63
Unit cell:
a: 65.61Å b: 65.61Å c: 131.7Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.209 0.282
Expression system: Bacteria

Quick links

Citations

27 review citations

TNF alpha and the TNF receptor superfamily: structure-function relationship(s).
Idriss et al. (2000)
26 more

4 mentions without citation

The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily.
Won et al. (2010)
3 more