› 1d33

X-ray diffraction
1.5Å resolution

Formaldehyde cross-links daunorubicin and DNA efficiently: HPLC and X-RAY diffraction studies

Released:
DOI: 10.2210/pdb1d33/pdb
PDB entry 1d33 coloured by chain, front view.
PDB entry 1d33 coloured by chain, side view.
PDB entry 1d33 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Formaldehyde cross-links daunorubicin and DNA efficiently: HPLC and X-ray diffraction studies.
Wang AH, Gao YG, Liaw YC, Li YK
Biochemistry 30 3812-5 (1991)
PMID: 2018756

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113594 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*CP*GP*CP*(G49)P*CP*G)-3' Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 1.82 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand DM1 1 x DM1
Ligand MG 1 x MG
1 modified residue:
Ligand G49 1 x G49

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P41212
Unit cell:
a: 27.943Å b: 27.943Å c: 52.243Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 not available not available
Expression system: Not provided

Quick links

Citations

7 review citations

Mitoxantrone, More than Just Another Topoisomerase II Poison.
Evison et al. (2016)
6 more

2 mentions without citation

Unraveling the sequence-dependent polymorphic behavior of d(CpG) steps in B-DNA.
Dans et al. (2014)
1 more