› 1d36

X-ray diffraction
1.5Å resolution

FACILE FORMATION OF A CROSSLINKED ADDUCT BETWEEN DNA AND THE DAUNORUBICIN DERIVATIVE MAR70 MEDIATED BY FORMALDEHYDE: MOLECULAR STRUCTURE OF THE MAR70-D(CGTNACG) COVALENT ADDUC

Released:
DOI: 10.2210/pdb1d36/pdb
PDB entry 1d36 coloured by chain, front view.
PDB entry 1d36 coloured by chain, side view.
PDB entry 1d36 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Facile formation of a crosslinked adduct between DNA and the daunorubicin derivative MAR70 mediated by formaldehyde: molecular structure of the MAR70-d(CGTnACG) covalent adduct.
Gao YG, Liaw YC, Li YK, van der Marel GA, van Boom JH, Wang AH
Proc Natl Acad Sci U S A 88 4845-9 (1991)
PMID: 2052564

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113596 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*TP*AP*CP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand MAR 1 x MAR
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P41212
Unit cell:
a: 28.01Å b: 28.01Å c: 53.11Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.164 not available not available
Expression system: Not provided

Quick links

Citations

3 review citations

Anthracycline antibiotics in cancer therapy. Focus on drug resistance.
Booser et al. (1994)
2 more

1 mention without citation

Unraveling the sequence-dependent polymorphic behavior of d(CpG) steps in B-DNA.
Dans et al. (2014)