› 1d37

X-ray diffraction
1.8Å resolution

INFLUENCE OF AGLYCONE MODIFICATIONS ON THE BINDING OF ANTHRACYCLINE DRUGS TO DNA: THE MOLECULAR STRUCTURE OF IDARUBICIN AND 4-O-DEMETHYL-11-DEOXYDOXORUBICIN COMPLEXED TO D(CGATCG)

Released:
DOI: 10.2210/pdb1d37/pdb
PDB entry 1d37 coloured by chain, front view.
PDB entry 1d37 coloured by chain, side view.
PDB entry 1d37 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Influence of aglycone modifications on the binding of anthracycline drugs to DNA: the molecular structure of idarubicin and 4-O-demethyl-11-deoxydoxorubicin complexed to d(CGATCG).
Gao YG, Wang AH
Anticancer Drug Des 6 137-49 (1991)
PMID: 1872945

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113597 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*AP*TP*CP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand DM4 1 x DM4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P41212
Unit cell:
a: 28.18Å b: 28.18Å c: 53.14Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 not available not available
Expression system: Not provided

Quick links

Citations

10 citation in other articles

A new paradigm for pattern recognition of drugs.
Potemkin et al. (2008)
9 more

2 mentions without citation

DNA conformations and their sequence preferences.
Svozil et al. (2008)
1 more