› 1d54

X-ray diffraction
1.4Å resolution

ANTHRACYCLINE BINDING TO DNA: HIGH RESOLUTION STRUCTURE OF D(TGTACA) COMPLEXED WITH 4'-EPIADRIAMYCIN

Released:
DOI: 10.2210/pdb1d54/pdb
PDB entry 1d54 coloured by chain, front view.
PDB entry 1d54 coloured by chain, side view.
PDB entry 1d54 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Anthracycline binding to DNA. High-resolution structure of d(TGTACA) complexed with 4'-epiadriamycin.
Leonard GA, Brown T, Hunter WN
Eur. J. Biochem. 204 69-74 (1992)
PMID: 1740157

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113614 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*TP*GP*TP*AP*CP*A)-3') Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand DM6 1 x DM6
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P41212
Unit cell:
a: 28.02Å b: 28.02Å c: 52.93Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 not available not available
Expression system: Not provided

Quick links

Citations

2 review citations

Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.
Sheng et al. (2013)
1 more

2 mentions without citation

DNA conformations and their sequence preferences.
Svozil et al. (2008)
1 more