› 1d5c

X-ray diffraction
2.3Å resolution

CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM RAB6 COMPLEXED WITH GDP

Released:
DOI: 10.2210/pdb1d5c/pdb
PDB entry 1d5c coloured by chain, front view.
PDB entry 1d5c coloured by chain, side view.
PDB entry 1d5c coloured by chain, top view.
Source organism: Plasmodium falciparum
Primary publication:
Structure of the nucleotide-binding domain of Plasmodium falciparum rab6 in the GDP-bound form.
Chattopadhyay D, Langsley G, Carson M, Recacha R, DeLucas L, Smith C
Acta Crystallogr D Biol Crystallogr 56 937-44 (2000)
PMID: 10944329

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173235 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTPase (Rab6) Chain: A
Molecule details ›
Chain: A
Length: 162 amino acids
Theoretical weight: 18.74 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q26000 (Residues: 11-172; Coverage: 78%)
Gene name: rab6
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand GDP 1 x GDP
1 modified residue:
Ligand MSE 3 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS
Spacegroup: P43212
Unit cell:
a: 81.2Å b: 81.2Å c: 90.84Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 0.246
Expression system: Escherichia coli

Quick links

Citations

4 review citations

The Rab GTPase family.
Stenmark et al. (2001)
3 more

7 mentions without citation

Structural mechanisms for regulation of membrane traffic by rab GTPases.
Lee et al. (2009)
6 more