› 1d64

X-ray diffraction
2.1Å resolution

CRYSTAL STRUCTURE OF A PENTAMIDINE-OLIGONUCLEOTIDE COMPLEX: IMPLICATIONS FOR DNA-BINDING PROPERTIES

Released:
DOI: 10.2210/pdb1d64/pdb
PDB entry 1d64 coloured by chain, front view.
PDB entry 1d64 coloured by chain, side view.
PDB entry 1d64 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Crystal structure of a pentamidine-oligonucleotide complex: implications for DNA-binding properties.
Edwards KJ, Jenkins TC, Neidle S
Biochemistry 31 7104-9 (1992)
PMID: 1643044

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113624 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 3.66 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand PNT 1 x PNT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR571
Spacegroup: P212121
Unit cell:
a: 24.37Å b: 40Å c: 66.07Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 not available not available
Expression system: Not provided

Quick links

Citations

15 review citations

Antiparasitic compounds that target DNA.
Wilson et al. (2008)
14 more

10 mentions without citation

Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.
Sheng et al. (2013)
9 more