› 1d9s

Solution NMR

TUMOR SUPPRESSOR P15(INK4B) STRUCTURE BY COMPARATIVE MODELING AND NMR DATA

Released:
DOI: 10.2210/pdb1d9s/pdb
PDB entry 1d9s coloured by chain, ensemble of 10 models, front view.
PDB entry 1d9s coloured by chain, ensemble of 10 models, side view.
PDB entry 1d9s coloured by chain, ensemble of 10 models, top view.
Source organism: Mus musculus
Primary publication:
Tumor suppressor INK4: comparisons of conformational properties between p16(INK4A) and p18(INK4C).
Yuan C, Li J, Selby TL, Byeon IJ, Tsai MD
J Mol Biol 294 201-11 (1999)
PMID: 10556039

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157288 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 4 inhibitor B Chain: A
Molecule details ›
Chain: A
Length: 136 amino acids
Theoretical weight: 14.36 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P55271 (Residues: 1-130; Coverage: 100%)
Gene name: Cdkn2b
Sequence domains:
Structure domains: Ankyrin repeat-containing domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: COMPARATIVE MODELING, RESTRAINT ENERGY MINIMIZATION
Expression system: Escherichia coli

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Citations

2 review citations

Selectivity and potency of cyclin-dependent kinase inhibitors.
Sridhar et al. (2006)
1 more

8 mentions without citation

A primer on ankyrin repeat function in TRP channels and beyond.
Gaudet R. (2008)
7 more