PDB 1dan structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Reaction catalysed:

Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.

Biochemical function:

calcium ion binding

Biological process:

blood coagulation

Cellular component:

membrane

Sequence domains:

11 more domains

Structure domains:

Structure analysis Details

Assembly composition:

hetero tetramer (preferred)

Assembly name:

Coagulation factor VIIa complex and Tissue factor (preferred)

PDBe Complex ID:

PDB-CPX-140353 (preferred)

Entry contents:

4 distinct polypeptide molecules

Macromolecules (4 distinct):

Factor VII light chain Chain: L

Molecule details ›

Chain: L
Length: 152 amino acids
Theoretical weight: 17.49 KDa
Source organism: Homo sapiens
Expression system: Mesocricetus auratus
UniProt:

Canonical: P08709 (Residues: 61-212; Coverage: 34%)

Gene name: F7
Sequence domains:

Factor VII heavy chain Chain: H

Molecule details ›

Chain: H
Length: 254 amino acids
Theoretical weight: 28.1 KDa
Source organism: Homo sapiens
Expression system: Mesocricetus auratus
UniProt:

Canonical: P08709 (Residues: 213-466; Coverage: 57%)

Gene name: F7
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Tissue factor Chain: T

Molecule details ›

Chain: T
Length: 80 amino acids
Theoretical weight: 9.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:

Canonical: P13726 (Residues: 37-116; Coverage: 30%)

Gene name: F3
Sequence domains: Tissue factor
Structure domains: Immunoglobulins

Tissue factor Chain: U

Molecule details ›

Chain: U
Length: 121 amino acids
Theoretical weight: 13.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt: