› 1dgi

Electron Microscopy
22Å resolution

Cryo-EM structure of human poliovirus(serotype 1)complexed with three domain CD155

Released:
DOI: 10.2210/pdb1dgi/pdb
PDB entry 1dgi coloured by chain, front view.
PDB entry 1dgi coloured by chain, side view.
PDB entry 1dgi coloured by chain, top view.
Source organisms:
Primary publication:
Interaction of the poliovirus receptor with poliovirus.
He Y, Bowman VD, Mueller S, Bator CM, Bella J, Peng X, Baker TS, Wimmer E, Kuhn RJ, Rossmann MG
Proc Natl Acad Sci U S A 97 79-84 (2000)
PMID: 10618374

Function and Biology Details

Reactions catalysed: 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero 300-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136702 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Poliovirus receptor Chain: R
Molecule details ›
Chain: R
Length: 302 amino acids
Theoretical weight: 32.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P15151 (Residues: 28-329; Coverage: 76%)
Gene names: PVR, PVS
Sequence domains:
Capsid protein VP1 Chain: 1
Molecule details ›
Chain: 1
Length: 288 amino acids
Theoretical weight: 31.87 KDa
Source organism: Poliovirus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: P03300 (Residues: 595-881; Coverage: 13%)
Sequence domains: picornavirus capsid protein
Capsid protein VP2 Chain: 2
Molecule details ›
Chain: 2
Length: 268 amino acids
Theoretical weight: 29.66 KDa
Source organism: Poliovirus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: P03300 (Residues: 74-341; Coverage: 12%)
Sequence domains: picornavirus capsid protein
Capsid protein VP3 Chain: 3
Molecule details ›
Chain: 3
Length: 235 amino acids
Theoretical weight: 26.24 KDa
Source organism: Poliovirus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: P03300 (Residues: 342-576; Coverage: 11%)
Sequence domains: picornavirus capsid protein
Capsid protein VP4 Chain: 4
Molecule details ›
Chain: 4
Length: 63 amino acids
Theoretical weight: 6.98 KDa
Source organism: Poliovirus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: P03300 (Residues: 2-69; Coverage: 3%)
Sequence domains: Picornavirus coat protein (VP4)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 22Å
Expression system: Homo sapiens

Quick links

Citations

31 review citations

Foot-and-mouth disease.
Grubman et al. (2004)
30 more

7 mentions without citation

Evolution of cell recognition by viruses: a source of biological novelty with medical implications.
Baranowski et al. (2003)
6 more