› 1dgm

X-ray diffraction
1.8Å resolution

CRYSTAL STRUCTURE OF ADENOSINE KINASE FROM TOXOPLASMA GONDII

Released:
DOI: 10.2210/pdb1dgm/pdb
PDB entry 1dgm coloured by chain, front view.
PDB entry 1dgm coloured by chain, side view.
PDB entry 1dgm coloured by chain, top view.
Source organism: Toxoplasma gondii
Primary publication:
Crystal structure of adenosine kinase from Toxoplasma gondii at 1.8 A resolution.
Cook WJ, DeLucas LJ, Chattopadhyay D
Protein Sci 9 704-12 (2000)
PMID: 10794412

Function and Biology Details

Reaction catalysed: 
ATP + adenosine = ADP + AMP
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193585 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine kinase Chain: A
Molecule details ›
Chain: A
Length: 363 amino acids
Theoretical weight: 38.42 KDa
Source organism: Toxoplasma gondii
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9TVW2 (Residues: 1-363; Coverage: 100%)
Gene name: AK
Sequence domains: pfkB family carbohydrate kinase
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand MG 1 x MG
Ligand CL 1 x CL
Ligand ADN 1 x ADN
Ligand ACY 1 x ACY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 47.55Å b: 68.75Å c: 57.29Å
α: 90° β: 100.3° γ: 90°
R-values:
R R work R free
0.214 0.214 0.233
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Adenosine kinase: exploitation for therapeutic gain.
Boison D. (2013)
4 more

1 mention without citation

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Darme et al. (2021)