› 1dl4

Solution NMR

THE SOLUTION STRUCTURE OF A BAY-REGION 1S-BENZ[A]ANTHRACENE OXIDE ADDUCT AT THE N6 POSITION OF ADENINE OF AN OLIGODEOXYNUCLEOTIDE CONTAINING THE HUMAN N-RAS CODON 61 SEQUENCE

Released:
DOI: 10.2210/pdb1dl4/pdb
PDB entry 1dl4 coloured by chain, front view.
PDB entry 1dl4 coloured by chain, side view.
PDB entry 1dl4 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Intercalation of the (1S,2R,3S,4R)-N6-[1-(1,2,3,4-tetrahydro-2,3, 4-trihydroxybenz[a]anthracenyl)]-2'-deoxyadenosyl adduct in an oligodeoxynucleotide containing the human N-ras codon 61 sequence.
Li Z, Kim HY, Tamura PJ, Harris CM, Harris TM, Stone MP
Biochemistry 38 16045-57 (1999)
PMID: 10587427

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113686 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
DNA (5'-D(*CP*GP*GP*AP*CP*(BZA)AP*AP*GP*AP*AP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 11 nucleotides
Theoretical weight: 3.42 KDa
Source organism: Synthetic construct
Expression system: Not provided
DNA (5'-D(*CP*TP*TP*CP*TP*TP*GP*TP*CP*CP*G)-3') Chain: B
Molecule details ›
Chain: B
Length: 11 nucleotides
Theoretical weight: 3.29 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand BZA 1 x BZA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: NOE-RESTRAINTED MOLECULAR DYNAMICS /SIMULATED ANNEALING
Expression system: Not provided

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Citations

3 review citations

Repair-Resistant DNA Lesions.
Geacintov et al. (2017)
2 more