› 1dl8

X-ray diffraction
1.55Å resolution

CRYSTAL STRUCTURE OF 5-F-9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE BOUND TO D(CGTACG)2

Released:
DOI: 10.2210/pdb1dl8/pdb
PDB entry 1dl8 coloured by chain, front view.
PDB entry 1dl8 coloured by chain, side view.
PDB entry 1dl8 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Acridinecarboxamide topoisomerase poisons: structural and kinetic studies of the DNA complexes of 5-substituted 9-amino-(N-(2-dimethylamino)ethyl)acridine-4-carboxamides.
Adams A, Guss JM, Collyer CA, Denny WA, Prakash AS, Wakelin LP
Mol Pharmacol 58 649-58 (2000)
PMID: 10953060

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113687 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*TP*AP*CP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand DA7 2 x DA7
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P64
Unit cell:
a: 30.14Å b: 30.14Å c: 39.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.216 0.214 0.269
Expression system: Not provided

Quick links

Citations

1 review citation

Analytical methods for kinetic studies of biological interactions: A review.
Zheng et al. (2015)
12 other articles

3 mentions without citation

DNA conformations and their sequence preferences.
Svozil et al. (2008)
2 more