Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:
Structure analysis Details
Assemblies composition:
Assembly name:
alpha-thrombin complex and Fibrinopeptide A (preferred)
PDBe Complex ID:
PDB-CPX-133067 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Thrombin light chain
Molecule details ›
Chain: A
Length: 35 amino acids
Theoretical weight: 3.94 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Thrombin light chain
Length: 35 amino acids
Theoretical weight: 3.94 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical:
P00734 (Residues: 328-362; Coverage: 6%)
Sequence domains: Thrombin light chain
Thrombin heavy chain
Molecule details ›
Chain: B
Length: 260 amino acids
Theoretical weight: 29.92 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 260 amino acids
Theoretical weight: 29.92 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P00734 (Residues: 363-622; Coverage: 44%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Fibrinopeptide A
Molecule details ›
Chain: C
Length: 11 amino acids
Theoretical weight: 1.05 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Length: 11 amino acids
Theoretical weight: 1.05 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P02671 (Residues: 26-35; Coverage: 1%)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
RIGAKU RU200
Spacegroup:
I213
Expression system: Not provided
