› 1dqt

X-ray diffraction
2Å resolution

THE CRYSTAL STRUCTURE OF MURINE CTLA4 (CD152)

Released:
DOI: 10.2210/pdb1dqt/pdb
PDB entry 1dqt coloured by chain, front view.
PDB entry 1dqt coloured by chain, side view.
PDB entry 1dqt coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of murine CTLA-4 and its role in modulating T cell responsiveness.
Ostrov DA, Shi W, Schwartz JC, Almo SC, Nathenson SG
Science 290 816-9 (2000)
PMID: 11052947

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-140749 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytotoxic T-lymphocyte protein 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 117 amino acids
Theoretical weight: 12.93 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P09793 (Residues: 38-154; Coverage: 62%)
Gene names: Cd152, Ctla4
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand CL 4 x CL
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: P43212
Unit cell:
a: 112.85Å b: 112.85Å c: 102.504Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.211 0.254
Expression system: Escherichia coli

Quick links

Citations

35 review citations

CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy.
Chambers et al. (2001)
34 more

6 mentions without citation

Domain metastability: a molecular basis for immunoglobulin deposition?
Sonnen et al. (2010)
5 more