› 1dsc

Solution NMR

NMR STUDY OF DNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*C)-3') SELF-COMPLEMENTARY DUPLEX COMPLEXED WITH ACTINOMYCIN D, MINIMIZED AVERAGE STRUCTURE

Released:
DOI: 10.2210/pdb1dsc/pdb
PDB entry 1dsc coloured by chain, front view.
PDB entry 1dsc coloured by chain, side view.
PDB entry 1dsc coloured by chain, top view.
Source organism: Streptomyces antibioticus
Primary publication:
Structure of Actinomycin D Bound with (Gaagcttc)2 and (Gatgcttc)2 and its Binding to the (Cag)N:(Ctg)N Triplet Sequence by NMR Analysis
Lian C, Robinson H, Wang AH-J
J. Am. Chem. Soc. 118 8791- (1996)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-113708 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
ACTINOMYCIN D Chain: C
Molecule details ›
Chain: C
Length: 11 amino acids
Theoretical weight: 1.26 KDa
Source organism: Streptomyces antibioticus
DNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*C)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 8 nucleotides
Theoretical weight: 2.43 KDa
Source organism: Streptomyces antibioticus
Expression system: Not provided

Ligands and Environments

No bound ligands
3 modified residues:
Ligand DVA 2 x DVA
Ligand SAR 2 x SAR
Ligand MVA 2 x MVA

Experiments and Validation Details

Entry percentile scores
Refinement method: NOE-RMD
Expression system: Not provided

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