› 1dsx

X-ray diffraction
1.6Å resolution

KV1.2 T1 DOMAIN, RESIDUES 33-119, T46V MUTANT

Released:
DOI: 10.2210/pdb1dsx/pdb
PDB entry 1dsx coloured by chain, front view.
PDB entry 1dsx coloured by chain, side view.
PDB entry 1dsx coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel.
Minor DL, Lin YF, Mobley BC, Avelar A, Jan YN, Jan LY, Berger JM
Cell 102 657-70 (2000)
PMID: 11007484

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158995 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium voltage-gated channel subfamily A member 2 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 87 amino acids
Theoretical weight: 10.5 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P63142 (Residues: 33-119; Coverage: 17%)
Gene name: Kcna2
Sequence domains: BTB/POZ domain
Structure domains: Potassium Channel Kv1.1; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 76.39Å b: 78.398Å c: 126.924Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.237 0.279
Expression system: Escherichia coli

Quick links

Citations

24 review citations

Molecular physiology and modulation of somatodendritic A-type potassium channels.
Jerng et al. (2004)
23 more

1 mention without citation

Tetramerization domain mutations in KCNA5 affect channel kinetics and cause abnormal trafficking patterns.
Burg et al. (2010)