› 1dto

X-ray diffraction
1.9Å resolution

CRYSTAL STRUCTURE OF THE COMPLETE TRANSACTIVATION DOMAIN OF E2 PROTEIN FROM THE HUMAN PAPILLOMAVIRUS TYPE 16

Released:
DOI: 10.2210/pdb1dto/pdb
PDB entry 1dto coloured by chain, front view.
PDB entry 1dto coloured by chain, side view.
PDB entry 1dto coloured by chain, top view.
Source organism: Human papillomavirus type 16
Primary publication:
Structure of the intact transactivation domain of the human papillomavirus E2 protein.
Antson AA, Burns JE, Moroz OV, Scott DJ, Sanders CM, Bronstein IB, Dodson GG, Wilson KS, Maitland NJ
Nature 403 805-9 (2000)
PMID: 10693813

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136580 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Regulatory protein E2 Chain: A
Molecule details ›
Chain: A
Length: 221 amino acids
Theoretical weight: 25.7 KDa
Source organism: Human papillomavirus type 16
Expression system: Escherichia coli
UniProt:
  • Canonical: P03120 (Residues: 1-201; Coverage: 55%)
Gene name: E2
Sequence domains: E2 (early) protein, N terminal
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P3121
Unit cell:
a: 54.68Å b: 54.68Å c: 155.73Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.236 0.232 0.305
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Pathogenesis of human papillomaviruses in differentiating epithelia.
Longworth et al. (2004)
8 more

10 mentions without citation

The papillomavirus E2 proteins.
McBride AA. (2013)
9 more