› 1dtv

Solution NMR

NMR STRUCTURE OF THE LEECH CARBOXYPEPTIDASE INHIBITOR (LCI)

Released:
DOI: 10.2210/pdb1dtv/pdb
PDB entry 1dtv coloured by chain, front view.
PDB entry 1dtv coloured by chain, side view.
PDB entry 1dtv coloured by chain, top view.
Source organism: Hirudo medicinalis
Primary publication:
Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2.
Reverter D, Fernández-Catalán C, Baumgartner R, Pfänder R, Huber R, Bode W, Vendrell J, Holak TA, Avilés FX
Nat Struct Biol 7 322-8 (2000)
PMID: 10742178

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160531 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metallocarboxypeptidase inhibitor Chain: A
Molecule details ›
Chain: A
Length: 67 amino acids
Theoretical weight: 7.4 KDa
Source organism: Hirudo medicinalis
UniProt:
  • Canonical: P81511 (Residues: 15-81; Coverage: 100%)
Structure domains: Carboxypeptidase inhibitor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing

Quick links

Citations

8 review citations

Evolutionary families of peptidase inhibitors.
Rawlings et al. (2004)
7 more

1 mention without citation

A Coarse-Grained Methodology Identifies Intrinsic Mechanisms That Dissociate Interacting Protein Pairs.
Abdizadeh et al. (2020)