› 1dtx

X-ray diffraction
2.2Å resolution

CRYSTAL STRUCTURE OF ALPHA-DENDROTOXIN FROM THE GREEN MAMBA VENOM AND ITS COMPARISON WITH THE STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR

Released:
DOI: 10.2210/pdb1dtx/pdb
PDB entry 1dtx coloured by chain, front view.
PDB entry 1dtx coloured by chain, side view.
PDB entry 1dtx coloured by chain, top view.
Source organism: Dendroaspis angusticeps
Primary publication:
Crystal structure of alpha-dendrotoxin from the green mamba venom and its comparison with the structure of bovine pancreatic trypsin inhibitor.
Skarzy��ski T
J. Mol. Biol. 224 671-83 (1992)
PMID: 1373774

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133768 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kunitz-type serine protease inhibitor homolog alpha-dendrotoxin Chain: A
Molecule details ›
Chain: A
Length: 59 amino acids
Theoretical weight: 7.07 KDa
Source organism: Dendroaspis angusticeps
Expression system: Not provided
UniProt:
  • Canonical: P00980 (Residues: 1-59; Coverage: 100%)
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

1 bound ligand:
Ligand SO4 5 x SO4
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 73.53Å b: 39.06Å c: 23.15Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 not available not available
Expression system: Not provided

Quick links

Citations

7 review citations

Twenty years of dendrotoxins.
Harvey AL. (2001)
6 more

18 mentions without citation

Animal, Herb, and Microbial Toxins for Structural and Pharmacological Study of Acid-Sensing Ion Channels.
Osmakov et al. (2020)
17 more