› 1duq

X-ray diffraction
2.1Å resolution

CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1

Released:
DOI: 10.2210/pdb1duq/pdb
PDB entry 1duq coloured by chain, front view.
PDB entry 1duq coloured by chain, side view.
PDB entry 1duq coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
The crystal structure of the Rev binding element of HIV-1 reveals novel base pairing and conformational variability.
Hung LW, Holbrook EL, Holbrook SR
Proc Natl Acad Sci U S A 97 5107-12 (2000)
PMID: 10792052

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195995 (preferred)
Entry contents:
2 distinct RNA molecules
Macromolecules (2 distinct):
THE REV BINDING ELEMENT Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 12 nucleotides
Theoretical weight: 3.92 KDa
Source organism: Synthetic construct
Expression system: Not provided
THE REV BINDING ELEMENT Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 14 nucleotides
Theoretical weight: 4.46 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand NA 10 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P1
Unit cell:
a: 23.993Å b: 53.93Å c: 64.729Å
α: 114.52° β: 89.88° γ: 102.85°
R-values:
R R work R free
0.221 0.218 0.269
Expression system: Not provided

Quick links

Citations

4 review citations

Fluorescence-based methods for evaluating the RNA affinity and specificity of HIV-1 Rev-RRE inhibitors.
Luedtke et al. (2003)
3 more

7 mentions without citation

Structural and computational studies of HIV-1 RNA.
Levintov et al. (2024)
6 more