› 1dv8

X-ray diffraction
2.3Å resolution

CRYSTAL STRUCTURE OF THE CARBOHYDRATE RECOGNITION DOMAIN OF THE H1 SUBUNIT OF THE ASIALOGLYCOPROTEIN RECEPTOR

Released:
DOI: 10.2210/pdb1dv8/pdb
PDB entry 1dv8 coloured by chain, front view.
PDB entry 1dv8 coloured by chain, side view.
PDB entry 1dv8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor.
Meier M, Bider MD, Malashkevich VN, Spiess M, Burkhard P
J Mol Biol 300 857-65 (2000)
PMID: 10891274

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139494 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Asialoglycoprotein receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 15.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07306 (Residues: 154-281; Coverage: 44%)
Gene names: ASGR1, CLEC4H1
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

2 bound ligands:
Ligand CA 3 x CA
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELLIOTT GX-20
Spacegroup: C2
Unit cell:
a: 113.72Å b: 32.46Å c: 40.82Å
α: 90° β: 91.29° γ: 90°
R-values:
R R work R free
0.195 0.195 0.247
Expression system: Escherichia coli

Quick links

Citations

21 review citations

The C-type lectin-like domain superfamily.
Zelensky et al. (2005)
20 more

25 mentions without citation

Chemistry, structure and function of approved oligonucleotide therapeutics.
Egli et al. (2023)
24 more