› 1dvp

X-ray diffraction
2Å resolution

CRYSTAL STRUCTURE OF THE VHS AND FYVE TANDEM DOMAINS OF HRS, A PROTEIN INVOLVED IN MEMBRANE TRAFFICKING AND SIGNAL TRANSDUCTION

Released:
DOI: 10.2210/pdb1dvp/pdb
PDB entry 1dvp coloured by chain, front view.
PDB entry 1dvp coloured by chain, side view.
PDB entry 1dvp coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction.
Mao Y, Nickitenko A, Duan X, Lloyd TE, Wu MN, Bellen H, Quiocho FA
Cell 100 447-56 (2000)
PMID: 10693761

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188292 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte growth factor-regulated tyrosine kinase substrate Chain: A
Molecule details ›
Chain: A
Length: 220 amino acids
Theoretical weight: 25.12 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: Q960X8 (Residues: 1-219; Coverage: 29%)
Gene names: CG2903, Hrs
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand CIT 1 x CIT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: C2
Unit cell:
a: 116.706Å b: 69.665Å c: 41.799Å
α: 90° β: 94.77° γ: 90°
R-values:
R R work R free
0.227 0.215 0.254
Expression system: Escherichia coli

Quick links

Citations

36 review citations

Synthesis and function of 3-phosphorylated inositol lipids.
Vanhaesebroeck et al. (2001)
35 more

15 mentions without citation

Membrane fission reactions of the mammalian ESCRT pathway.
McCullough et al. (2013)
14 more