› 1dvr

X-ray diffraction
2.36Å resolution

STRUCTURE OF A MUTANT ADENYLATE KINASE LIGATED WITH AN ATP-ANALOGUE SHOWING DOMAIN CLOSURE OVER ATP

Released:
DOI: 10.2210/pdb1dvr/pdb
PDB entry 1dvr coloured by chain, front view.
PDB entry 1dvr coloured by chain, side view.
PDB entry 1dvr coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Structure of a mutant adenylate kinase ligated with an ATP-analogue showing domain closure over ATP.
Schlauderer GJ, Proba K, Schulz GE
J Mol Biol 256 223-7 (1996)
PMID: 8594191

Function and Biology Details

Reaction catalysed: 
ATP + AMP = 2 ADP
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139419 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenylate kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 220 amino acids
Theoretical weight: 24.01 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P07170 (Residues: 3-222; Coverage: 99%)
Gene names: ADK1, AKY, AKY1, AKY2, YD9934.11, YDR226W
Sequence domains:
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:
Ligand ATF 2 x ATF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 47.8Å b: 73.4Å c: 118.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.191 not available
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Thermodynamics of protein-ligand interactions: history, presence, and future aspects.
Perozzo et al. (2004)
4 more

22 mentions without citation

Zipping and unzipping of adenylate kinase: atomistic insights into the ensemble of open<-->closed transitions.
Beckstein et al. (2009)
21 more