› 1dxx

X-ray diffraction
2.6Å resolution

N-terminal Actin-binding Domain of Human Dystrophin

Released:
DOI: 10.2210/pdb1dxx/pdb
PDB entry 1dxx coloured by chain, front view.
PDB entry 1dxx coloured by chain, side view.
PDB entry 1dxx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the N-terminal actin-binding domain of human dystrophin and how mutations in this domain may cause Duchenne or Becker muscular dystrophy.
Norwood FL, Sutherland-Smith AJ, Keep NH, Kendrick-Jones J
Structure 8 481-91 (2000)
PMID: 10801490

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145868 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dystrophin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 246 amino acids
Theoretical weight: 28.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P11532 (Residues: 1-246; Coverage: 7%)
Gene name: DMD
Sequence domains: Calponin homology (CH) domain
Structure domains: Calponin-like domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P1
Unit cell:
a: 59.69Å b: 79.33Å c: 81.95Å
α: 61.08° β: 78.22° γ: 70.54°
R-values:
R R work R free
0.232 0.232 0.268
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

23 review citations

The muscular dystrophies.
Emery AE. (2002)
22 more

18 mentions without citation

How Structural Biologists and the Protein Data Bank Contributed to Recent FDA New Drug Approvals.
Westbrook et al. (2019)
17 more