› 1dza

X-ray diffraction
1.65Å resolution

Function and Biology Details

Reaction catalysed: 
(1a) an (RNA) containing cytidine = an (RNA)-3'-cytidine-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139880 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribonuclease pancreatic Chains: A, B
Molecule details ›
Chains: A, B
Length: 129 amino acids
Theoretical weight: 14.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P07998 (Residues: 28-156; Coverage: 100%)
Gene names: RIB1, RNASE1, RNS1
Sequence domains: Pancreatic ribonuclease
Structure domains: Ribonuclease A-like domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand FME 2 x FME

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7A
Spacegroup: P212121
Unit cell:
a: 27.85Å b: 67.42Å c: 114.14Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.185 0.236
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

15 citation in other articles

Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein.
Johnson et al. (2007)
14 more

6 mentions without citation

The role of human ribonuclease A family in health and diseases: A systematic review.
Sun et al. (2022)
5 more