› 1dzi

X-ray diffraction
2.1Å resolution

integrin alpha2 I domain / collagen complex

Released:
DOI: 10.2210/pdb1dzi/pdb
PDB entry 1dzi coloured by chain, front view.
PDB entry 1dzi coloured by chain, side view.
PDB entry 1dzi coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of collagen recognition by integrin alpha2beta1.
Emsley J, Knight CG, Farndale RW, Barnes MJ, Liddington RC
Cell 101 47-56 (2000)
PMID: 10778855

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148026 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Integrin alpha-2 Chain: A
Molecule details ›
Chain: A
Length: 185 amino acids
Theoretical weight: 20.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17301 (Residues: 171-355; Coverage: 16%)
Gene names: CD49B, ITGA2
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain
COLLAGEN Chains: B, C, D
Molecule details ›
Chains: B, C, D
Length: 22 amino acids
Theoretical weight: 2.01 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CO 1 x CO
1 modified residue:
Ligand HYP 18 x HYP

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX7.2
Spacegroup: P212121
Unit cell:
a: 41.994Å b: 48.377Å c: 114.545Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.2 not available
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

136 review citations

Integrins: bidirectional, allosteric signaling machines.
Hynes RO. (2002)
135 more

45 mentions without citation

Collagen structure and stability.
Shoulders et al. (2009)
44 more