› 1e2x

X-ray diffraction
2Å resolution

FadR, fatty acid responsive transcription factor from E. coli

Released:
DOI: 10.2210/pdb1e2x/pdb
PDB entry 1e2x coloured by chain, front view.
PDB entry 1e2x coloured by chain, side view.
PDB entry 1e2x coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Crystal structure of FadR, a fatty acid-responsive transcription factor with a novel acyl coenzyme A-binding fold.
van Aalten DM, DiRusso CC, Knudsen J, Wierenga RK
EMBO J 19 5167-77 (2000)
PMID: 11013219

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-141750 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fatty acid metabolism regulator protein Chain: A
Molecule details ›
Chain: A
Length: 243 amino acids
Theoretical weight: 27.49 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A8V6 (Residues: 1-239; Coverage: 100%)
Gene names: JW1176, b1187, fadR, oleR, thdB
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: C2221
Unit cell:
a: 59.711Å b: 101.973Å c: 87.513Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.2 0.237
Expression system: Escherichia coli

Quick links

Citations

17 review citations

Bacterial transcriptional regulators for degradation pathways of aromatic compounds.
Tropel et al. (2004)
16 more

17 mentions without citation

The structural basis of acyl coenzyme A-dependent regulation of the transcription factor FadR.
van Aalten et al. (2001)
16 more