› 1e3b

X-ray diffraction
1.85Å resolution

CYCLOPHILIN 3 FROM C.ELEGANS COMPLEXED WITH AUP(ET)3

Released:
DOI: 10.2210/pdb1e3b/pdb
PDB entry 1e3b coloured by chain, front view.
PDB entry 1e3b coloured by chain, side view.
PDB entry 1e3b coloured by chain, top view.
Source organism: Caenorhabditis elegans
Primary publication:
First Crystal Structure of a Medicinally Relevant Gold Protein Complex: Unexpected Binding of.
Zou J, Taylor P, Dornan J, Robinson SP, Walkinshaw MD, Sadler PJ
Angew Chem Int Ed Engl 39 2931-2934 (2000)
PMID: 11028014

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156454 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase 3 Chain: A
Molecule details ›
Chain: A
Length: 173 amino acids
Theoretical weight: 18.58 KDa
Source organism: Caenorhabditis elegans
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P52011 (Residues: 1-173; Coverage: 100%)
Gene names: Y75B12B.5, cyn-3, cyp-3
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

2 bound ligands:
Ligand AU 1 x AU
Ligand 3EP 1 x 3EP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.5
Spacegroup: P41212
Unit cell:
a: 61.157Å b: 61.157Å c: 123.077Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 not available 0.247
Expression system: Escherichia coli BL21

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Citations

6 review citations

On the potential of thioredoxin reductase inhibitors for cancer therapy.
Urig et al. (2006)
5 more