› 1e9w

X-ray diffraction
1.02Å resolution

Structure of the macrocycle thiostrepton solved using the anomalous dispersive contribution from sulfur

Released:
DOI: 10.2210/pdb1e9w/pdb
PDB entry 1e9w coloured by chain, front view.
PDB entry 1e9w coloured by chain, side view.
PDB entry 1e9w coloured by chain, top view.
Source organism: Streptomyces azureus
Primary publication:
Structure of the macrocycle thiostrepton solved using the anomalous dispersion contribution of sulfur.
Bond CS, Shaw MP, Alphey MS, Hunter WN
Acta Crystallogr D Biol Crystallogr 57 755-8 (2001)
PMID: 11320328

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143178 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thiostrepton Chain: A
Molecule details ›
Chain: A
Length: 19 amino acids
Theoretical weight: 1.81 KDa
Source organism: Streptomyces azureus
UniProt:
  • Canonical: P0C8P8 (Residues: 56-72; Coverage: 24%)
Gene name: tpdA

Ligands and Environments

No bound ligands
6 modified residues:
Ligand DHA 3 x DHA
Ligand BB9 4 x BB9
Ligand DBU 1 x DBU
Ligand DCY 1 x DCY
Ligand TS9 1 x TS9
Ligand MH6 1 x MH6

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P43212
Unit cell:
a: 26.577Å b: 26.577Å c: 27.436Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.112 not available 0.142

Quick links

Citations

2 review citations

From amino acids to heteroaromatics--thiopeptide antibiotics, nature's heterocyclic peptides.
Hughes et al. (2007)
1 more

6 mentions without citation

Virus membrane fusion.
Weissenhorn et al. (2007)
5 more