› 1ebp

X-ray diffraction
2.8Å resolution

COMPLEX BETWEEN THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP] AND AN AGONIST PEPTIDE [EMP1]

Released:
DOI: 10.2210/pdb1ebp/pdb
PDB entry 1ebp coloured by chain, front view.
PDB entry 1ebp coloured by chain, side view.
PDB entry 1ebp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A.
Livnah O, Stura EA, Johnson DL, Middleton SA, Mulcahy LS, Wrighton NC, Dower WJ, Jolliffe LK, Wilson IA
Science 273 464-71 (1996)
PMID: 8662530

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148531 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Erythropoietin receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 211 amino acids
Theoretical weight: 23.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19235 (Residues: 34-244; Coverage: 44%)
Gene name: EPOR
Sequence domains:
Structure domains: Immunoglobulins
EPO MIMETICS PEPTIDE 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 20 amino acids
Theoretical weight: 2.1 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 59.24Å b: 75.5Å c: 132.18Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.21 0.334
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

96 review citations

Alternative activation of macrophages: an immunologic functional perspective.
Martinez et al. (2009)
95 more

19 mentions without citation

Computational prediction of protein hot spot residues.
Morrow et al. (2012)
18 more