› 1edh

X-ray diffraction
2Å resolution

E-CADHERIN DOMAINS 1 AND 2 IN COMPLEX WITH CALCIUM

Released:
DOI: 10.2210/pdb1edh/pdb
PDB entry 1edh coloured by chain, front view.
PDB entry 1edh coloured by chain, side view.
PDB entry 1edh coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis of calcium-induced E-cadherin rigidification and dimerization.
Nagar B, Overduin M, Ikura M, Rini JM
Nature 380 360-4 (1996)
PMID: 8598933

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140757 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 226 amino acids
Theoretical weight: 24.72 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P09803 (Residues: 156-380; Coverage: 26%)
Gene name: Cdh1
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

2 bound ligands:
Ligand HG 2 x HG
Ligand CA 6 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: C2
Unit cell:
a: 121.657Å b: 80.802Å c: 72.635Å
α: 90° β: 116.65° γ: 90°
R-values:
R R work R free
0.206 0.206 0.262
Expression system: Escherichia coli

Quick links

Citations

106 review citations

Molecular and functional analysis of cadherin-based adherens junctions.
Yap et al. (1997)
105 more

31 mentions without citation

Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells.
Phan et al. (2007)
30 more