› 1ee0

X-ray diffraction
2.05Å resolution

2-PYRONE SYNTHASE COMPLEXED WITH ACETOACETYL-COA

Released:
DOI: 10.2210/pdb1ee0/pdb
PDB entry 1ee0 coloured by chain, front view.
PDB entry 1ee0 coloured by chain, side view.
PDB entry 1ee0 coloured by chain, top view.
Source organism: Gerbera hybrid cultivar
Primary publication:
Structural control of polyketide formation in plant-specific polyketide synthases.
Jez JM, Austin MB, Ferrer J, Bowman ME, Schr��der J, Noel JP
Chem. Biol. 7 919-30 (2000)
PMID: 11137815

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155721 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
2-pyrone synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 402 amino acids
Theoretical weight: 43.83 KDa
Source organism: Gerbera hybrid cultivar
Expression system: Escherichia coli
UniProt:
  • Canonical: P48391 (Residues: 1-402; Coverage: 100%)
Gene names: 2PS, CHS2
Sequence domains:
Structure domains: Peroxisomal Thiolase; Chain A, domain 1

Ligands and Environments

1 bound ligand:
Ligand CAA 2 x CAA
1 modified residue:
Ligand CSD 2 x CSD

Experiments and Validation Details

Entry percentile scores
X-ray source: MACSCIENCE
Spacegroup: P3121
Unit cell:
a: 83.406Å b: 83.406Å c: 240.625Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.189 0.243
Expression system: Escherichia coli

Quick links

Citations

20 review citations

Natural products and plant disease resistance.
Dixon RA. (2001)
19 more

8 mentions without citation

Structural assembly of two-domain proteins by rigid-body docking.
Cheng et al. (2008)
7 more