› 1eea

X-ray diffraction
4.5Å resolution

Acetylcholinesterase

Released:
DOI: 10.2210/pdb1eea/pdb
PDB entry 1eea coloured by chain, front view.
PDB entry 1eea coloured by chain, side view.
PDB entry 1eea coloured by chain, top view.
Source organism: Electrophorus electricus
Primary publication:
Quaternary Structure of Tetrameric Acetylcholinesterase
Raves ML, Giles K, Schrag JD, Schmid MF, Phillips Jr GN, Wah C, Howard AJ, Silman I, Sussman JL, Doctor BP, Quinn DM, Rotundo RL, Taylor P
Structure and Function of Cholinesterases and Related Proteins (1998)

Function and Biology Details

Reaction catalysed: 
Acetylcholine + H(2)O = choline + acetate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137375 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetylcholinesterase Chain: A
Molecule details ›
Chain: A
Length: 534 amino acids
Theoretical weight: 60.46 KDa
Source organism: Electrophorus electricus
UniProt:
  • Canonical: P04058 (Residues: 22-555; Coverage: 95%)
Gene name: ache
Sequence domains: Carboxylesterase family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: F222
Unit cell:
a: 140.86Å b: 201.46Å c: 235.77Å
α: 90° β: 90° γ: 90°

Quick links

Citations

11 mentions without citation

Tetrameric mouse acetylcholinesterase: continuum diffusion rate calculations by solving the steady-state Smoluchowski equation using finite element methods.
Zhang et al. (2005)
10 more