› 1eg6

X-ray diffraction
2Å resolution

CRYSTAL STRUCTURE ANALYSIS OF D(CG(5-BRU)ACG) COMPLEXES TO A PHENAZINE

Released:
DOI: 10.2210/pdb1eg6/pdb
PDB entry 1eg6 coloured by chain, front view.
PDB entry 1eg6 coloured by chain, side view.
PDB entry 1eg6 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Guanine specific binding at a DNA junction formed by d[CG(5-BrU)ACG](2) with a topoisomerase poison in the presence of Co(2+) ions.
Thorpe JH, Hobbs JR, Todd AK, Denny WA, Charlton P, Cardin CJ
Biochemistry 39 15055-61 (2000)
PMID: 11106483

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113735 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*CP*GP*(BRO)UP*AP*CP*G)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 6 nucleotides
Theoretical weight: 1.8 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand 3CO 2 x 3CO
Ligand BR 2 x BR
Ligand BFA 1 x BFA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X31
Spacegroup: C222
Unit cell:
a: 29.42Å b: 53.44Å c: 41.32Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.228 0.347
Expression system: Not provided

Quick links

Citations

1 review citation

Non-G Base Tetrads.
Escaja et al. (2022)
13 other articles

2 mentions without citation

Interactions of small molecules with DNA junctions.
McQuaid et al. (2022)
1 more