› 1ehw

X-ray diffraction
2.4Å resolution

HUMAN NUCLEOSIDE DIPHOSPHATE KINASE 4

Released:
DOI: 10.2210/pdb1ehw/pdb
Model geometry
Fit model/data
Data not deposited
PDB entry 1ehw coloured by chain, front view.
PDB entry 1ehw coloured by chain, side view.
PDB entry 1ehw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase.
Milon L, Meyer P, Chiadmi M, Munier A, Johansson M, Karlsson A, Lascu I, Capeau J, Janin J, Lacombe ML
J Biol Chem 275 14264-72 (2000)
PMID: 10799505

Function and Biology Details

Reaction catalysed: 
(1) a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside5'-triphosphate + ADP.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126380 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoside diphosphate kinase, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 162 amino acids
Theoretical weight: 18.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00746 (Residues: 31-175; Coverage: 78%)
  • Best match: O00746-2 (Residues: 1-105)
Gene names: NM23D, NME4
Sequence domains: Nucleoside diphosphate kinase
Structure domains: Nucleoside diphosphate kinase-like domain

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: LURE BEAMLINE DW32
Spacegroup: P213
Unit cell:
a: 112.96Å b: 112.96Å c: 112.96Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.184 0.229
Expression system: Escherichia coli

Quick links

Citations

25 review citations

Mitochondrial creatine kinase in human health and disease.
Schlattner et al. (2006)
24 more

7 mentions without citation

NME/NM23/NDPK and Histidine Phosphorylation.
Adam et al. (2020)
6 more