› 1em0

X-ray diffraction
0.9Å resolution

COMPLEX OF D(CCTAGG) WITH TETRA-[N-METHYL-PYRIDYL] PORPHYRIN

Released:
DOI: 10.2210/pdb1em0/pdb
PDB entry 1em0 coloured by chain, front view.
PDB entry 1em0 coloured by chain, side view.
PDB entry 1em0 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
A DNA-porphyrin minor-groove complex at atomic resolution: the structural consequences of porphyrin ruffling.
Bennett M, Krah A, Wien F, Garman E, McKenna R, Sanderson M, Neidle S
Proc Natl Acad Sci U S A 97 9476-81 (2000)
PMID: 10920199

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113748 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*(CBR)P*CP*TP*AP*GP*G)-3') Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 6 nucleotides
Theoretical weight: 1.89 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand MG 2 x MG
Ligand PNI 2 x PNI
1 modified residue:
Ligand CBR 4 x CBR

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14, EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P41
Unit cell:
a: 32.21Å b: 32.21Å c: 62.257Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.151 0.152 0.172
Expression system: Not provided

Quick links

Citations

3 review citations

G-quadruplexes as therapeutic targets.
Neidle et al. (2000)
2 more

1 mention without citation

DNA conformations and their sequence preferences.
Svozil et al. (2008)