Function and Biology Details
Reaction catalysed:
(S)-dihydroorotate + NAD(+) = orotate + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
- Dihydroorotate dehydrogenase, conserved site
- Dihydroorotate dehydrogenase, catalytic
- Dihydroorotate dehydrogenase, electron transfer subunit, Fe-S binding domain superfamily
- Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain
- Oxidoreductase FAD/NAD(P)-binding
- Dihydroorotate dehydrogenase electron transfer subunit
- Riboflavin synthase-like beta-barrel
6 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Dihydroorotate dehydrogenase B (NAD(+)), (preferred)
PDBe Complex ID:
PDB-CPX-157010 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit
Molecule details ›
Chain: A
Length: 311 amino acids
Theoretical weight: 32.98 KDa
Source organism: Lactococcus lactis
Expression system: Escherichia coli
UniProt:
Sequence domains: Dihydroorotate dehydrogenase
Structure domains: Aldolase class I
Length: 311 amino acids
Theoretical weight: 32.98 KDa
Source organism: Lactococcus lactis
Expression system: Escherichia coli
UniProt:
- Canonical:
P54322 (Residues: 1-311; Coverage: 100%)
Sequence domains: Dihydroorotate dehydrogenase
Structure domains: Aldolase class I
Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit
Molecule details ›
Chain: B
Length: 261 amino acids
Theoretical weight: 28.56 KDa
Source organism: Lactococcus lactis
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 261 amino acids
Theoretical weight: 28.56 KDa
Source organism: Lactococcus lactis
Expression system: Escherichia coli
UniProt:
- Canonical: P56968 (Residues: 2-262; Coverage: 100%)
Sequence domains:
- Oxidoreductase NAD-binding domain
- Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
