› 1ete

X-ray diffraction
2.2Å resolution

CRYSTAL STRUCTURE OF THE FLT3 LIGAND

Released:
DOI: 10.2210/pdb1ete/pdb
PDB entry 1ete coloured by chain, front view.
PDB entry 1ete coloured by chain, side view.
PDB entry 1ete coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots.
Savvides SN, Boone T, Andrew Karplus P
Nat Struct Biol 7 486-91 (2000)
PMID: 10881197

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-156022 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fms-related tyrosine kinase 3 ligand Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 134 amino acids
Theoretical weight: 15.45 KDa
Source organism: Homo sapiens
Expression system: Bacteria
UniProt:
  • Canonical: P49771 (Residues: 27-160; Coverage: 64%)
Gene name: FLT3LG
Sequence domains: flt3 ligand
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

1 bound ligand:
Ligand ZN 9 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P21212
Unit cell:
a: 137.08Å b: 159.41Å c: 26.25Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.239 0.287
Expression system: Bacteria

Quick links

Citations

7 review citations

The role of Kit-ligand in melanocyte development and epidermal homeostasis.
Wehrle-Haller B. (2003)
6 more

4 mentions without citation

Inducible production of recombinant human Flt3 ectodomain variants in mammalian cells and preliminary crystallographic analysis of Flt3 ligand-receptor complexes.
Verstraete et al. (2011)
3 more