› 1etn

X-ray diffraction
0.89Å resolution

MOLECULAR STRUCTURE OF THE TOXIC DOMAIN OF HEAT-STABLE ENTEROTOXIN PRODUCED BY A PATHOGENIC STRAIN OF ESCHERICHIA COLI

Released:
DOI: 10.2210/pdb1etn/pdb
PDB entry 1etn coloured by chain, front view.
PDB entry 1etn coloured by chain, side view.
PDB entry 1etn coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Molecular structure of the toxin domain of heat-stable enterotoxin produced by a pathogenic strain of Escherichia coli. A putative binding site for a binding protein on rat intestinal epithelial cell membranes.
Ozaki H, Sato T, Kubota H, Hata Y, Katsube Y, Shimonishi Y
J Biol Chem 266 5934-41 (1991)
PMID: 2005130

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134389 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat-stable enterotoxin ST-IA/ST-P Chain: A
Molecule details ›
Chain: A
Length: 13 amino acids
Theoretical weight: 1.26 KDa
Source organism: Escherichia coli
Expression system: Not provided
UniProt:
  • Canonical: P01559 (Residues: 60-71; Coverage: 23%)
Gene name: sta1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 21.01Å b: 27.621Å c: 12.781Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.088 0.088 not available
Expression system: Not provided

Quick links

Citations

14 review citations

Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion.
Sears et al. (1996)
13 more

19 mentions without citation

Molecular mechanisms of enterotoxigenic Escherichia coli infection.
Fleckenstein et al. (2010)
18 more