› 1evn

Solution NMR

NMR OBSERVATION OF A-TETRAD

Released:
DOI: 10.2210/pdb1evn/pdb
PDB entry 1evn coloured by chain, ensemble of 7 models, front view.
PDB entry 1evn coloured by chain, ensemble of 7 models, side view.
PDB entry 1evn coloured by chain, ensemble of 7 models, top view.
Source organism: Synthetic construct
Primary publication:
NMR studies on truncated sequences of human telomeric DNA: observation of a novel A-tetrad.
Patel PK, Koti AS, Hosur RV
Nucleic Acids Res 27 3836-43 (1999)
PMID: 10481022

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113770 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*AP*GP*GP*GP*T)-3') Chains: M, N, O, P
Molecule details ›
Chains: M, N, O, P
Length: 5 nucleotides
Theoretical weight: 1.56 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Restrained energy minimization, simulated annealing-restrained molecular dynamics. Iterative relaxation matrix refinement
Expression system: Not provided

Quick links

Citations

9 review citations

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.
Patel et al. (2007)
8 more

3 mentions without citation

Non-G Base Tetrads.
Escaja et al. (2022)
2 more