› 1exf

X-ray diffraction
2.1Å resolution

EXFOLIATIVE TOXIN A

Released:
DOI: 10.2210/pdb1exf/pdb
PDB entry 1exf coloured by chain, front view.
PDB entry 1exf coloured by chain, side view.
PDB entry 1exf coloured by chain, top view.
Source organism: Staphylococcus aureus
Primary publication:
The structure of the superantigen exfoliative toxin A suggests a novel regulation as a serine protease.
Vath GM, Earhart CA, Rago JV, Kim MH, Bohach GA, Schlievert PM, Ohlendorf DH
Biochemistry 36 1559-66 (1997)
PMID: 9048539

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140613 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Exfoliative toxin A Chain: A
Molecule details ›
Chain: A
Length: 242 amino acids
Theoretical weight: 26.99 KDa
Source organism: Staphylococcus aureus
UniProt:
  • Canonical: P09331 (Residues: 39-280; Coverage: 100%)
Gene name: eta
Sequence domains: Trypsin-like peptidase domain
Structure domains: Trypsin-like serine proteases

Ligands and Environments

1 bound ligand:
Ligand GLY 1 x GLY
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P43212
Unit cell:
a: 71.5Å b: 71.5Å c: 122.86Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.172 0.204

Quick links

Citations

26 review citations

Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome.
Stanley et al. (2006)
25 more

3 mentions without citation

Exfoliative toxins of Staphylococcus aureus.
Bukowski et al. (2010)
2 more