› 1ext

X-ray diffraction
1.85Å resolution

EXTRACELLULAR DOMAIN OF THE 55KDA TUMOR NECROSIS FACTOR RECEPTOR. CRYSTALLIZED AT PH3.7 IN P 21 21 21.

Released:
DOI: 10.2210/pdb1ext/pdb
PDB entry 1ext coloured by chain, front view.
PDB entry 1ext coloured by chain, side view.
PDB entry 1ext coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of the extracellular domain of the type I tumor necrosis factor receptor.
Naismith JH, Devine TQ, Kohno T, Sprang SR
Structure 4 1251-62 (1996)
PMID: 8939750

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148577 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor-binding protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 162 amino acids
Theoretical weight: 18.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19438 (Residues: 41-201; Coverage: 38%)
Gene names: TNFAR, TNFR1, TNFRSF1A
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2

Ligands and Environments

2 bound ligands:
Ligand SO4 3 x SO4
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.5
Spacegroup: P212121
Unit cell:
a: 78.81Å b: 83.06Å c: 67.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.203 0.243
Expression system: Escherichia coli

Quick links

Citations

26 review citations

The molecular architecture of the TNF superfamily.
Bodmer et al. (2002)
25 more

34 mentions without citation

Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases.
Alexander et al. (2014)
33 more